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KMID : 0380620180500060629
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 6 p.629 ~ p.635
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Toxicokinetics and oral toxicity of Maesil-cheongs with reduced amygdalin levels
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Kim Hyeon-Jin
Go Mi-Ran
Yu Jin
Hwang Ji-Soo
Choi Hyun-Woo
Kim Hyun-Seok
Choi Soo-Jin
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Abstract
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In this study, the safety aspect of Maesil-cheongs with reduced amygdalin levels was investigated in terms of toxicokinetics and repeated oral toxicity. Plasma or UVC treatment was utilized to obtain Maesil-cheongs with reduced amygdalin levels. The toxicokinetic study demonstrated that the oral absorption of amygdalin decreased remarkably after a single-dose oral administration of both plasma- and UVC-treated Maesil-cheongs. The fourteen-day repeated oral toxicity study revealed that plasma- or UVC-treated Maesil-cheongs did not cause changes in body weight, food intake, water consumption, and absolute and relative organ weights. No significant effects on hematological and serum biochemical parameters were found. Histopathological examination showed no abnormality or toxicological change. These findings suggest that plasma- and UVC-treated Maesil-cheongs have no toxicity potential, and these processes will be useful to obtain products with safe, reduced amygdalin levels.
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KEYWORD
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Maesil-cheong, amygdalin, toxicokinetics, oral toxicity
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